Abstract
Background: Brucellosis is one of the most common bacterial zonosis. Different cytokines have an important role in the pathogenesis of the causative bacteria. Interferon-γ (IFN-γ) and interleukin-12 (IL-12) are among the most essential cytokines required for the elimination of infection with Brucella.Aims: The study aimed to measure serum levels of IFN-γ, IL-12 and IL-8 and correlation among these cytokines in patients with brucellosis.Subjects and Methods: A total of 60 patients with brucellosis and 26 apparently healthy controls were enrolled in this study. From each participant, blood samples were collected from which serum was obtained. Enzyme-linked immunosorbent assay was used to estimate serum levels of IFN-γ, IL-12 and IL-8 in each serum sample.Results: Serum levels of IFN-γ and IL-12 but not IL-8 were significantly higher in patients with brucellosis compared to control. Furthermore, serum levels of IFN-γ correlated positively with IL-12 and negatively with IL-8.Conclusion: Both IFN-γ and IL-12 have a crucial role in the immunity and pathogenesis of Brucella and can be used as indication for chronic infection.
Article Type
Article
Recommended Citation
Habeeb, Thuraya Aamer
(2026)
"Serum Levels of Interferon-γ, Interleukin-12 and Interleukin-8 in Patients with Brucellosis,"
Al-Qadisiyah Medical Journal: Vol. 11:
Iss.
20, Article 17.
DOI: 10.28922/qmj.2015.11.20.117-122
Available at:
https://qmj.qu.edu.iq/journal/vol11/iss20/17
First Page
117
Last Page
122
Rights
Copyright (c) 2017 AL-QADISIYAH MEDICAL JOURNAL
