Study the impact of serum melatonin level on male infertility and reproductive hormones and its correlation to semen parameters

Authors

• fahad alsalih, University of AL-Qadisiyah; College of Medicine, IraqIntroduction:The World Health Organization (WHO) defines infertility as the failure to achieve pregnancy after one year of regular unprotected coitus. There are many potential causes of male infertility, including anatomical abnormalities, sexual dysfunction, varicocele, obesity, oligospermia, smoking, and heavy metal toxicity (1). Infertility is the problem of 15% of young couples in different countries and male factor infertility accounts for 50% of cases. Thus, any support for this issue would develop the health status of the human being (2). Male infertility has been linked to genetic and pathological factors such as abnormal hormonal levels, varicocele, cystic fibrosis gene mutations, Y chromosome abnormalities, testicular cancer, epigenetic errors, pituitary tumors, and even idiopathic factors (3). Moreover, it has been indicated that environmental, occupational, and lifestyle factors can affect male infertility, compromising sperm quality. Indeed, studies have demonstrated that elements like alcohol consumption, cigarette smoking, obesity, radiation, genital heat stress, dietary practices, and illicit drug use contribute to a decline in human sperm quality (4). Treatment for male infertility depends on the underlying cause. Options include medication to improve sperm production, surgery to correct

Abstract

Infertility is the inability of couples to achieve pregnancy after one year of regular unprotected coitus. Infertility is the problem of 15% of young couples in different countries and male factor infertility accounts for 50% of cases. Melatonin or 5-methoxy-N-acetyltryptamine was discovered by Aaron Lerner in 1958 while studying bovine pineal glands. Significant advancements have been made in the research on melatonin, which has revealed its vital roles in regulating sleep-wake cycle rhythms, decelerating the aging process, and functioning as an antioxidant or anti-inflammatory agent. Additionally, melatonin, a critical component in reproductive functions, has the ability to eliminate free radicals such as (ROS).

Article Type

Article

Recommended Citation

alsalih, fahad (2026) "Study the impact of serum melatonin level on male infertility and reproductive hormones and its correlation to semen parameters," Al-Qadisiyah Medical Journal: Vol. 19: Iss. 1, Article 2.
DOI: 10.28922/qmj.2023.19.1.4-8
Available at: https://qmj.qu.edu.iq/journal/vol19/iss1/2

First Page

4

Last Page

8

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