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Abstract

Abstract  Background:  Synthetic derivatives differ in their metabolic and electrolyte-regulating activities. These agents are employed at physiological doses for replacement therapy when endogenous product is impaired. While corticosteroids are relatively inexpensive & commonly used as treatment for a variety of conditions, long term use is known to be associated with certain toxicities. Increasing use of topical and systemic steroids for treatment many skin problems lead to increase there side effects. Recently, steroid components have been synthesized that aim to have adequate anti-inflammatory effects and minimal adverse effects. The newest topical corticosteroids used for the treatment of different dermatoses and allergic reactions  are budesonide, mometasone furoate, prednicarbate, the di-esters 17,21-hydrocortisone aceponate and hydrocortisone-17-butyrate-21-propionate, methylprednisolone aceponate, alclometasone dipropionate, and carbothioates such as fluticasone propionate. These new topical corticosteroids are evaluated in the current review, which compares the risk/benefit ratio of each molecule with established agents. The new molecules, compared with the well known and established corticosteroids, generally have a higher anti-inflammatory effect, good compliance among patients (only a once-daily application is needed), rarely induce cross-sensitivity reactions and have weak atrophogenicity.

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Article

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69

Last Page

72

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