Sirtuin 1 and vitamin D3 as prognostic factors for chronic kidney diseases and nephrotic syndrome

Authors

• Fatima Al-Zahra’a ’Mohammed Radhi, Branch of Medical Chemistry, College of Medicine, University of Al-Qadisiyah,
• Anwar Jasib Almzaiel, Branch of Medical Chemistry, College of Medicine, University of Al-Qadisiyah,

Abstract

Background: Kidney disease encompasses any form of damage or illness that affects these organs. Sirtuin-1 is an NAD+-dependent and class III histone deacetylase protein. Vitamin D3 is a fat-soluble steroid hormone. Recently, it was suggested that Sirtuin-1 and Vitamin D3 were involved in the pathogenesis of renal diseases. The exact protective mechanisms of Sirtuin-1 in renal diseases are still not completely understood. Objectives: The aim of this study was to explore the potential involvement of Sirtuin-1 in modulating the inflammatory response in various kidney diseases. Materials and Methods: The research study was carried out between October 2022 and April 2023. A total of ninety subjects participated in the study, including thirty patients with chronic kidney disease (16 females, 14 males), 2nd group include thirty patients with nephrotic syndrome (13 females, 17 males). 3rd control group consist of thirty subjects was also included in the study, consisting of nineteen females and eleven males, with a. Serum SIRT-1 and vitamin D3 were measured by Sandwich Enzyme Linked Immunosorbent Assay (ELISA). Blood urea nitrogen (BUN), serum creatinine, and serum albumin were measured by an automated Biorex diagnostics device. Results: The results clearly demonstrated that all patient groups had lower Sirtuin-1 levels than the control group (P ≤ 0.05). Serum Vitamin D3 levels were significantly lower in all patient groups as compared to the healthy group (P ≤ 0.05). Conclusions: Sirtuin-1 and Vitamin D3 play a critical role in inflammation and autophagy dysfunction in kidney tissue; thus, Sirtuin-1 activation and Vitamin D3 may alleviate inflammation in renal diseases and serve as potential therapeutic agents for the treatment of renal diseases.

Article Type

Review

Recommended Citation

Radhi, Fatima Al-Zahra’a ’Mohammed and Almzaiel, Anwar Jasib (2025) "Sirtuin 1 and vitamin D3 as prognostic factors for chronic kidney diseases and nephrotic syndrome," Al-Qadisiyah Medical Journal: Vol. 21: Iss. 2, Article 1.
Available at: https://qmj.qu.edu.iq/journal/vol21/iss2/1

First Page

78

Last Page

84

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