Abstract
Background: As the most common chronic skin illness with a genetic foundation, eczema is an inflammatory skin condition driven by cytokines. People with AD suffer from a significant burden that affects their physical, mental, social, and financial well-being. The cytokines are important in eczema disease. Interleukins regulate immunity. Lack impairs immunity or causes autoimmune disorders. Objectives: This study is aiming to investigate whether inflammatory cytokine (IL-4, IL-13) levels in the blood correlate with eczema disorder. Methods: This case-control study is based on 60 patients who have been diagnosed with eczema disorder with a 60-person apparently healthy control group. 4 ml of blood samples have been collected from each individual by using a sterile syringe under aseptic conditions and collected in a gel tube for serum separation. The serum levels of IL4 and IL13 IL4,IL13,were measured using the sandwich ELISA method according to the instruction manual. Results: According to the research findings, individuals with eczema disorder had considerably higher levels of IL-4 and IL-13 (P = 0.001). A positive correlation between IL-4 and IL-13 levels has also been demonstrated, which may indicate that these changes play a role in the development of eczema disease. Conclusions: This study established that the levels of IL-4 and IL-13 are strongly related with the risk of eczema in individuals in Diwaniyah Province, Iraq.
Article Type
Review
Recommended Citation
Murad, Shurooq Salim and Mohammad, Heyam Qaid
(2025)
"Serum Level of IL-4 and IL-13 and Their Association with Disease Pathogenesis in Patients with Eczema,"
Al-Qadisiyah Medical Journal: Vol. 21:
Iss.
2, Article 4.
Available at:
https://qmj.qu.edu.iq/journal/vol21/iss2/4
First Page
98
Last Page
102
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
