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Abstract

Abstract: This study evaluates and determines the therapeutic effects of platelet-rich plasma injection for the management of Peyronie’s disease and erectile dysfunction. Patients & Methods: From March 2021 until March 2022, a prospective study was conducted on 50 patients with Peyronie’s disease, erectile dysfunction, and penile curvature less than 60 degrees (mild to moderate penile curvature). All participants were subjected to 8 repeated injections of PRP weekly in the dominant penile plaque, with follow-up over 6 months of collected data that included orientation of curvature, injection technique, and the results in both quantitative (i.e., curvature estimations) and qualitative (erectile state and pain during intercourse) forms and complications. Results: 50 male patients with follow-up in pre- and post-injection regimes over periods of 2, 4, and 6 months; the results were collected. Only minor complications, i.e., mild penile swelling, bruising, edema, and allergy; important decrease in penile curvature comparable to baseline without noticeable worsening of curvature plaque in subsequent evaluations. Improvement in pain during sex (visual analog score) increased from 4 to 8. No significant improvement in ED compared to baseline (IIEF-5 score) Conclusion: PRP in treatment for Peyronie’s disease is safe, with unremarkable adverse effects and significant improvement in penile deformation. It is better for this therapeutic modality to be initiated in the early, i.e., active, phase of the disease since it is easy and well tolerated.

Article Type

Review

First Page

125

Last Page

128

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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