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Abstract

Background: Graves' disease is an autoimmune disorder that affects the thyroid gland, a small butterfly-shaped organ located in the anterior of the neck. In this case, the immune system mistakenly attacks the thyroid, leading to the overproduction of thyroid hormones. The most common result of Graves' disease is an overactive thyroid gland, which produces an excess of thyroid hormones (thyroxine or T4 and triiodothyronine or T3). This can lead to symptoms such as weight loss, rapid heartbeat, anxiety, irritability, heat intolerance, and increased sweating. The thyroid gland may become enlarged, causing a noticeable swelling in the front of the neck. Objectives: To check liver enzymes, calcium, and phosphorus in the sera of the Graves' disease patients and to compare these results with the control. Methods: Detection of ALT, AST, ALP, TSB, calcium, and phosphate The mentioned markers are measured by using the Roche Cobas C111 Chemistry Analyzer. The cobas c111 main instrument uses absorption photometry for determining the amount of absorbance in a fluid. The absorbance is used to calculate the concentration in the solution. Results: The \{mean ± SD\} of ages and genders among patients with healthy groups were not significant. Comparison of serum calcium and serum phosphate between the patient group and control group: There was no significant variance in mean serum calcium and mean serum phosphate between both subjects (p > 0.05). Comparison of liver function tests among patient groups and control subjects: There were no significant differences in median ALT, AST, ALP, and TBIL between patients and control subjects (p > 0.05). Conclusion: Serum calcium and phosphate are nearly comparable in GD patients and the control (9.45 ± 1.02 and 9.49 ± 0.76 and 3.93 ± 0.86 and 4 ± 1.85, respectively). Liver function tests, including ALT, AST, ALP, and bilirubin, show no significant variance between the patient subject and the control.

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8

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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