Jaundice occurs in most newborn infants. Most jaundice is benign, but because of the potential toxicity of bilirubin, newborn infants must be monitored to identify those who might develop severe hyperbilirubinemia and, in rare cases, acute bilirubin encephalopathy or kernicterus. Many factors may contributes to this unwanted outcome amongst this is the concentration of albumin. The focus of this guideline is to determine the relationship between the level of serum bilirubin and the concentration of the albumin in neonatal jaundice. The result revealed no significant changes was observed for the albumin concentration on the level of bilirubin.