Evaluation of efficacy of injection platelet rich plasma for the management of “Peyronie’s disease” and erectile dysfunction

Abstract

This study to evaluate and  determine the therapeutic effects of platelet rich plasma injection for the management of Peyronie’s disease and erectile dysfunction

Patients & Methods: From March  2021 until March 2022, prospective  study on 50 patients with Peyronie’s disease ,erectile dysfunction , and penile curvature  less than 60 degrees (mild to moderate penile  curvature).

all participant subjected to repeated 8  injections of PRP weekly  in dominant penile plaque with follow up over 6 months of collected  data included orientation of curvature , Injection technique, and the results in  both quantitative ie  curvature estimations  and qualitative  (erectile state and pain during intercourse), and complications.

Results: 50 male patients with follow up in pre- and post-injection regime over periods  2,4,and 6 months, the results were collected.

- only minor complications i.e mild penile swelling ,bruising  , edema and allergy

-important decrease in penile curvature comparable to baseline without notice  worsening of curvature plaque  in subsequent evaluations.

- Improvement in  Pain during sex (visual analoge score) increase  from  4 to 8

- No significant improvement in ED compare to baseline (IIEF-5 score) 20

Abbreviations  RPR platelet rich plasma, PD Peyronie’s disease

Conclusion

PRP in treatment for Peyronie’s Disease is safe, unremarkable adverse effect, With significant improvement in penile deformation, . it better with This therapeutic modality  to be  initiated in the early i.e active phase of the disease since it easy and well tolerated .