Association of lewis phenotype blood groups with recurrent urinary tract infection in female

Abstract

Background: Histo blood group antigens with carbohydrate molecules are found on the surface of RBC and uroepithelial cells, which influence human susceptibility to recurrent urinary tract infection( RUTI).
Objective: Of this study was to determine if a link exists between susceptibility to RUTI and host genetic phenotypes that define either an individual’s ability to respond immunologically to some antigens or the composition of host cell surface molecules. The interaction of pathogen and erythrocyte membrane may reflect antigenic similarity, adhesion through specific receptors, or modulation of antibody response, Detect the ABO blood group distribution and RUTI in accordance to lewis phenotype antigens,
Methods: The studied groups attended to Babylon Maternity and Pediatric Teaching Hospital from November, 2010 to November 2011. The study is carried out on 22 female as control groups, and 52 female as patient group. All patients had a history of RUTI, defined as a minimum of three infections in the previous year; however, most patients experienced more than three UTIs per year and had recurrent infections for several years. Results of excretory urography or renal ultrasound and cystoscopy performed on all patients were normal or showed only inflammatory changes. also using physical examination and urinalysis. Circulating immunoglobulin concentrations (IgG) was evaluated by applying Mancini single radial immunodiffusion technique for a RUTI patients and control involved in this study.
Results: - Regarding lewis phenotype blood group in RUTI women , there's association between non-secretor phenotype and predisposition to RUTIs in post menopause women and disappears in pregnant women in patient and control, while there's no association between secretor phenotype and predisposition to RUTIs in young women. The important result in this study appearance percent of weak secretor phenotype was (14%) in RUTI and control women. WBC count shows a highly significant increase (p<0.001), significant increase (p<0.05)of granulocyte and lymphocyte count in RUTI women in patents comparing with control groups. and significant increase (p<0.05) in secretor than non-secretor RUTI groups of WBC ,lymphocyte and granulocyte count . Also it was found that RUTI was associated with an increase in IgG concentration more than normal IgG concentrations among secretor RUTI patients revealed an increase more than non-secretor RUTI .While, urine analysis shows all patents were suffering with pyurea , these severity was highly significant increase (p<0.001) in nonsecretor than secretor RUTI group . Conclusion: the results of this study supports Predisposition RUTI has been associated with ABO histo Blood group and secretor status. The distribution of non-secretors was significantly higher in women with RUTI Than in the control, and higher in postmenopausal and pregnant women than in young women. These results suggest that non-secretor status is associated with the genetic susceptibility to RUTI.