A Study of Human Leukocyte Antigens-G (HLA-G), cANCA and pANCA in Inflammatory Bowel Diseases Patients

Abstract

Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the bowel, consisting mainly of Crohn’s disease (CD) and ulcerative colitis (UC). The incidence of IBD has been rising not only in Western countries, but also in Asia, the exact causes of both diseases are still a mystery. A total of forty two Iraqi patients from Al-Diwanyia province (15 females and 27 males) who have been diagnosed by specialist physicians in Al-Diwaniya Teaching Hospital for Gastrointestinal Tract and Hepatic diseases unit, compared with twenty one unrelated, healthy controls (10 females and 11 males). All patients was diagnosed by endoscopy and biopsy from the sites of inflammation (hitopathological method). The patients group was composed of two sub-groups; 38(90.5%) patients with Ulcerative Colitis and 4(9.5%) patients with Crohn's disease. The highest age incidence was above 40 years old (55.3% and 25% of UC and CD patients, respectively), followed by age of 30-39 years. The majority of UC (81.5 %) have shown positive results for p.ANCA, compared with (25 %) of CD patients, while all controls have given negative results for this test. Both of UC(47.4%) and CD(100%) patients shown positive results for HLA-G, while all healthy controls were given negative results for this test.