Several experiments were conducted, to determine the effects of extracts of vegetative parts of Lusha (Allium akaka) on growth of some human and plant pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, Xanthomonas campestris and Erwinia caratovora. Plant vegetative parts were extracted (crude extraction) using distilled water and ethanol (90%). Concentrations of 500, 1000, 5000 and10000ïg disc-1and ïg m-1were tested. Sterilized distilled water usedas control. CRD was applied with four replications, the results analyzed statistically using SPSS and the means were compared using Duncan Multiple Range Test at 0.01 level. Results showed that ethanol extracts were effective at concentration of 5000ïg disc-1and 10000ïg ml-1 against Staphylococcus aureus, Xanthomonas campestris and Erwinia caratovora while aqueous extract affected on Staphylococcus aureus at 10000 ïg ml-1 only. Escherichia coli were not affected by the plant extract at all concentrations used in this study. Agar disc diffusion technique was more effective than discsaturation method for determination of plant extract effects on thegrowth of bacteria.