This study shows the effect of chloramphicol drug on liver and kidney tissues in male rabbits. We used eight animals for each group . The first group used as a control by using physiological saline( 0.9%) concentration . The second group were taken the drug( 250 mg) for sixteen days. Biopsy were taken from the animals to examine their tissues histopathologically. Results were seen in liver tissues in the form of bleeding . cellular infiltration and necrosis .kidney tissues also reveal pathological changes like congestion and necrosis.