HLA types studied in sixty bladder cancer patients. A control sample of 80 apparently disease free individuals was included for comparisons, matched for ethinical background (Iraqi Arabs), sex and age. The study demonstrated significant deviations in four antigens, HLA -A2, -B5, -B51 and -Cw7, when comparisons was made between patients and controls. The frequency of antigen Cw7 was increased in the patients, while antigens A2, B5, and B51 showed decreased frequencies. Other associations were also observed when the tumour staging and grading were considered.