Effect Of Ablaquine Drug On P.Berghei In Vitro(II)

Abstract

The aim of the present study is to establishment of continuous culture of P.berghei using best suitable condition and also the effect of Aablaquine drug on in vitro invasion of P.berghei and the intracellular growth of the parasite .A short –term culture using different concentrations ( 10 , 100 , 250 , 500 , 1000 , μg/ml ) of Ablaquine drug along with controls was maitained in 24 well culture trays at 37 oC for 21 hr . The invasion inhibition was found to be directly proportional to the concentration of drug used . 74 % inhibition was recorded with 1000 μg/ml concentration of Ablaquine drug followed by 60 % , 58 % , 47 % , 32 % inhibition caused by 500 μg/ml , 250 μg/ml, 100 μg/ml and 10 μg/ml respectivelly .