Inflammation has been shown to play a role in atherosclerosis and CAD. An elevated leukocyte count is associated with adverse inhospital out come and mortality in patients presented with acutecoronarysyndrome. This study was designed to determine the relation between initial total WBC count and the hospital mortality and complications in patients with ACS including STEMI, NSTEMI, and UA and to know if this parameter has significant power of clinical severity and out come. Patients and methods: The relationship between initial total WBC count with hospital mortality and complications and clinical out come in 57 patients with ACS admitted to the CCU in ADDIWANYIA teaching hospital from the first of January to the 30 of march 2008 has been tested ,diseases were evaluated for seventeen (17) patients with STEMI ,twenty (20) patients with NSTEMI , twenty (20) patients with UA , venous blood samples were taking from each patient for initial total WBC count ,fasting lipid profile ,random blood sugar. Comparison between those patients with STEMI, NSTEMI, UA were conducted includes one inflammatory marker (WBC). High initial total WBC count was associated with high cardiovascular risk, heart failure and mortality (19.2%, 12.2 %, and 8.77 %) among patients with STEMI, NSTEMI, and UA respectively. Conclusion: In patients with ACS, initial leukocyte count is predictive of out come and as the level increased the complications increase and the clinical out come adversely affected.
