The present comprehensive study was designed to investigate the changes in some biochemical parameters and determine the risk factors in sera samples of patient with myocardial infarction (MI) [history of diabetes mellitus (DM) type 1, hypertension (blood pressure BP), and DM+ BP+smoking].Sixty four patients with MI attending to Merjan Teaching Hospital in Hilla City, were included in the present study. Also thirty two healthy individuals of matched age and gender were utilized as control.The main measurements included the following biochemical measurements:-Ceruloplasmin (CP), copper(Cu),total protein(TP) ,albumin(Alb.),globulin(Glo),total cholesterol(TC), triglyceride(TG), and total bilirubin(TB) concentrations, also Alb./Glo. ratio, TC/Alb ratio, CP oxidase activity, CP oxidase specific activity and Cu conc. / CP oxidase activity ratio in sera of healthy (control) and patients with MI (history of DM , BP and DM+BP+smoking).The results revealed a highly significant increase(p<0.001) in the CP, TP, Glo, TG, TB concentrations, Alb./Glo. ratio, CP oxidase activity, specific activity and Cu conc./CP oxidase activity ratio in sera of patients with MI (DM+ BP+smoking),while the same parameter referred significant increase(p<0.01) in patients with MI(DM or BP) in comparisom with control group. But Alb. concentration show significant decrease in the all groups (p<0.001), (p<0.01) respectively. An important finding in this study is that biochemical risk factors appeared to occur in patients with DM+BP+smoking more the patients with DM or BP. This observation suggests that DM+BP+smoking may be more prominent risk factor for MI. Hypertriglyceridemia, but not hypercholesterolemia, is associated with MI. TC/Alb ratio is considered a better index of cardiovascular risk than serum cholesterol. CP conc., CP activity and specific activity and Cu Conc. / CP oxidase activity anew biochemical parameters and risk factors, therefore this results it is regarded us a primary indicator to MI.
