EFFECTS OF ENAMINOTHIONES COMPOUNDS ON THE DERMATOPHYES AND YEAST ISOLATES IN VITRO

Abstract

Three enaminothione compounds namely 5,5- Dimethyl -3 N (N,N-Diethyl) phenylamino -2- Cyclohexane -1- thione ; 5, 5- Dimethyl -3N (4- Bromophenyl) amino -2- Cyclohexane -1- thione ; 5,5- Dimethyl -3N-phenyl) amino -2- Cyclohexane -1- thione were prepared and their U.V. and I.R. spectra were measured. The inhibitory activity of these compounds were tested by disc diffusion method against pathogenic fungi ( dermatophytes and yeast infections ) in vitro . Results revealed that synthesized compounds have an inhibitory effect against the tested fungal isolates . Introduction :- There has always a wide interest in certain type of schiff bases such as enaminothiones ( 1,2 ), and compounds containing thiol group because their inhibitory effects ( 3 ) . Superficial - Cutaneous mycotic infections constitute a group of microorganisms categorized as causing dermatophytosis and candidiasis (4). The development of new agents for the treatment of mycotic infections has been slow , and there are relatively few agents available , compared to the number that have been developed for treatment of bacterial infections (5). Recently , many synthetic drugs have been demonstrated to have in vitro and therapeutic activity against a variety of human fungal pathogens (6).