Evaluation Low Density Lipoprotein Cholesterol and Triglyceride Concentrations and Gene Expression of p53 may Predict the Risk for Breast Cancer

Abstract

Breast cancer is a condition in which cancerous cells in the breast tissue proliferate and divide uncontrollably. Through blood arteries or lymph, these cells infiltrate harmless surrounding tissues, where they cause the development of secondary cancer metastases . Abnormality in lipid metabolism (typically by poor diet or obesity) and cholesterol changes can be risky factor for cancer in breast have been subject to the substantial research. Circulating lipids not only associated with etiology but also with prognosis in cancer. Lipids are crucial in the emergence and progression of cancer. LDL-C has been linked to a higher risk of breast carcinoma. Overexpression of p53 gene could be predictive tumor marker for breast cancer diagnosis in risk group.