Sirtuin 1 and vitamin D3 as a therapeutic target for chronic kidney diseases and Nephrotic syndrome
Abstract
The kidneys are essential organs that are both intricate and crucial for maintaining the normal functions of the body. Kidney disease encompasses any form of damage or illness that affects these organs. The most prevalent kidney illnesses are CKD and NS, which frequently result in a decline in kidney function and, in severe cases, total kidney failure. SIRT-1, a NAD+-dependent class III histone deacetylase protein. Vitamin D3 is a fat-soluble steroid hormone. Recently, it was suggested that SIRT-1 and Vit.D3 were involved in pathogenesis of renal diseases. The exact protective mechanisms of SIRT-1 in renal diseases are still not completely understood.
Objectives: the aim of this study was to explore the potential involvement of SIRT-1 in modulating the inflammatory response in various kidney diseases. Additionally, the study aimed to investigate the levels of Sirt-1 and vitamin D3 in kidney diseases as prospective therapeutic agents for these conditions.
