10.28922 Evaluation of salivary matrix metalloproteinase -9 in patients with polycystic ovarian syndrome and periodontitis

Abstract

The objective of study is to evaluate the salivary levels of (MMP-9) in polycystic ovarian syndrome women with inflammation of periodontium in comparison to healthy control. The present study included a total of 85 subjects with an age range of 20 to 40 years. The current study included a control group (n = 10), patients suffering from periodontitis (n = 25), patients suffering from polycystic ovary syndrome (PCOS) (n= 25) and patients suffering from combined pathologies periodontitis and PCOS (n = 25). The median value of plaque index (PI) was highest in periodontitis group followed by combined group then by PCOS group and lastly by groups (p< 0.001). The results showed that control and PCOS groups had the lowest bleeding on probing median level, but it was significantly lower than that of periodontitis and combined groups (p< 0.001). On the other hand, the level in the PCOS group was significantly lower than that of periodontitis and combined groups (p< 0.001). The median level of PPD of periodontitis group was significantly lower in periodontitis group than that of combined group (p< 0.001). Intra-group comparison revealed that the median levels of MMP-9 in descending order was as following:  combined group then PCOS then periodontitis and lastly control group. Kruskal Wallis test demonstrated high significance difference (p < 0.001). PCOS is associated with more severe periodontal inflammation and tissue destruction in comparison with non-PCOS women. Salivary matrix metalloproteinase-9 is useful in predicting periodontitis in women with or without PCOS.