Association of soluble HLA-G expressions and their roles on the Risk of Recurrent Pregnancy Loss in Iraqi Populations.

Abstract

Background: Human Leukocyte Antigen –G HLA-G is a non-classical HLA class molecule that productions a central part in immune tolerance at the motherly fetal interface. Aim of study: The current study was designed to examine the relationship of HLA-G gene expression among recurrent pregnancy loss in Iraq. Methods: An entire of 40 females with idiopathic RPL were comprised in the training who stayed known to infertility, gynecological and obstructs department in Baghdad Hospital City from the period between February /2022–October/ 2022, and further groups comprise of 40 actually healthy persons. A three ml of blood samples were collected for polymerase chain reaction for Real Time polymerase chain reaction expression analysis quantification of HLA-G and housekeeping gene (GAPDH) in blood patients and normal samples by utilizing of Real-Time PCR process. Results: The present outcomes suggest that decreased mean of Human leukocyte antigen-G (HLA-G) gene appearance in sick females with RPL in compared with healthy controls. Conclusion: The current results identified an relationship HLA-G gene appearance and RPL development.