Role of MCP-1 serum level along with its genetic polymorphism in Open angle glaucoma disease susceptibility

الملخص

Abstract

Background: The chronic optic neuropathy known as slowly developing primary open-angle glaucoma (P.O.A.G) is characterised within unique patterns for optic nerve degeneration as well as vision field loss. is the most prevalent kind, a complicated, multidimensional illness with a pathophysiology influenced by both genetic and environmental variables. Objective: This study's objective is to find a relationship between polymorphisms of the MCP-1 gene and open-angle glaucoma disease susceptibility, along with their proposed role in disease pathogenesis. Materials and Methods: Two groups were the subjects of a case-control study: The first group included 40 patients who had previously been diagnosed with glaucoma, all cases that were observed in AL-Diwaniyah Teaching HospitalEye Department and ophthalmology private Al-hayat clinics AL-Qadisiyah, Iraq In the period from  October 2023 to December 2023, under the supervision of experienced ophthalmologist medicine specialists , information was collected about each case. From the patient, in addition to the tests that were performed in the center’s departments, such as: eye pressure and optical coherence tomography (OCT). The second group included 40 healthy volunteers (with no family history of glaucoma). Results: The current investigation revealed that the mean serum MCP-1 level in the patients group was noticeably higher than that of the control group, 3.63 ±2.45 pg\ml, opposing 1.51 ±0.66 pg\ml, In consequence, (p<0.001). Additionally, current investigation found that the genotypes AA, AG and GG showed no significant difference (p > 0.05) whenever contrasts emerged among the patient group as well as the control group.  Thus, none of them could consider this as a protective or hazardous element.

Conclusion:  This research found no significant association between the MCP-1 (2518A/G) polymorphism and the occurrence of primary open-angle glaucoma in sample of Iraqi individuals. However, its serum level reflects sign of involvement in pathogenesis and disease development.

Keywords: MCP-1, OCT, Genetic polymorphism, open-angle glaucoma disease.