the Assessment of Role IL-4and IL-13 in eczema Patients.

IL-4 andIL-13 in pathogenesis of eczema

الملخص

Background: As the most common chronic skin illness with a genetic foundation, eczema is an inflammatory skin condition driven by cytokines. People with AD suffer from a significant burden that affects their physical, mental, social, and financial well-being. The Cytokines are important in eczema disease. Interleukins regulate immunity. Lack impairs immunity or causes autoimmune disorders.
Objectives: This study is aiming to investigate whether inflammatory cytokines (IL-4 IL13) levels in the blood correlate with eczema disorder.
Methods: his case control study based on 60 patients who has been diagnosed with eczema disorder with 60 apparently healthy control group. 4ml of Blood samples has been collected from each individual by using sterile syringe under aseptic condition, and collected in gel tube for serum separation, The serum levels of IL4,IL13,were measured using sandwich ELISA method according to instruction manual.
Results: According to the research findings, individuals with eczema disorder had considerably higher levels of IL4 and IL13(P= 0.001) and could be used to tell the difference between Eczema patients and in apparently health the AUC analysis. A positive correlation between (IL4,IL13) levels has also been demonstrated, which may indicate that these changes play a role in the development of eczema disease.
Conclusions: This study clearly established that the levels of IL4, IL13 is strongly related with the risk of eczema in individuals in Diwaniyah Province, Iraq.