An Association of IL-23,, and IL-17 Levels with Alopecia Areata

IL-23,, and IL-17 and Alopecia Areata

الملخص

Abstract

background: Alopecia areata (AA) isa chronic, non-scarring autoimmune condition characterized by patchy hair losing. the abnormal regulation of pro-and anti-inflammatory cytokines is frequently associated with autoimmune diseases. Interleukin-17 (IL-17) as well as Interleukin 23(IL-23) are two of the substances that may be involved in the immunopathogenesis of AA. The purpose of the research was to assess AA patients' serum levels of IL-23 and IL17 as well as investigate any relationships they may have regarded the seriousness of their illness. materials and Methods: from December 2023 to April 2024 case-control research was carried out at AL-Diwaniya Teaching-Hospital. It comprised 40 formally identified A.A patients as well as 40 healthy- controls who were compared for gender as well as age. Comprehensive dermatology tests as well as a thorough history- taking process were performed on the participants. According to the quantity as well as size of alopecic patches or the degree of hair loss. AA was divided into moderate and severe variants. Levels of serum IL23- as well as IL17 were assessed as well as compared to illness feature. Results: compared to healthy controls,AA patients and noticeably higher levels of IL-17. Nevertheless, there was not a statistical significance variance in il-17 A levels according to the length of the illness, family history, or recurrent. IL-17A levels was slightly more elevated among participants with-out a family-history as well as those whose condition has been present for less than a year, but those variations weren't statistically significant. Furthermore, compared to controls, alcoholics IL-23 levels were noticeably greater. Conclusion: A.A patients had significantly higher serum levels of IL-23 as well as IL-17, which may indicate a function for these molecules in the pathophysiology of the disease. The autoimmune processes that underlie AA might get exacerbated by the dysregulation of these cytokines.