Impact of Renal Dysfunction on In-Hospital Outcomes in Patients with Acute Coronary Syndrome
Renal dysfunction & acute coronary syndrome
الكلمات المفتاحية:
Acute coronary syndrome; Renal dysfunction; Mortality; Morbidityالملخص
Background: The outcome is poor in patients with acute myocardial infarction(MI) who have renal dysfunction in long term follow up. Less is known about the outcome of acute MI in short term. We aimed to evaluate the outcome of patients with acute coronary syndrome(ACS) across varying degrees of renal dysfunction.
Patients and methods: Seventy patients presenting with ACS including ST segment elevation MI(STEMI), non-ST segment elevation MI(NSTEMI), and unstable angina (UA) were enrolled in this prospective observational study. Sociodemographic, clinical characteristics, and in hospital outcomes were compared for patients according to Glomerular filtration rate (GFR).
RESULTS: Patients with moderate to severe renal dysfunction were elderly female and associated with more comorbidities and adverse outcome if compared with patients who had normal to mild renal dysfunction. When the enrolled patients were divided into two groups: STEMI and NSTEMI/UA, a significant difference were observed between these two groups. There was no significant association between STEMI with occurrence of adverse outcomes and moderate to severe renal dysfunction presence. On the other hand, a significant association with occurrence of adverse outcomes among patients with NSTEMI/UA group.
Conclusion: Moderate to severe renal impairment is a predictor of in-hospital morbidity and mortality in ACS.
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