Fifty angina pectoris patients (APP) were clinically diagnosed in Mergan Hospital in Hillah city during the period from March to August 2009. While the control group were fifty normal subjects. APP and control groups were subjected to a battery of acute phase protein C, Anti DNA and IgM anti IgG to investigate the role of the auto-antibodies in the immunopathogenesis of angina pectoris (AP) . Thirty-five out of the fifty APP (70%) were positive for acute phase protein response with titre ranges of 18-128. while APP. were positive for Anti DNA and IgM anti IgG autoantibodies were 36% and 16% respectively with titre ranges of 16-32 and 4-32 respectively. The immunoprofile of APP was heterogeneic with eight different patterns. Aging and diabetic stats as clinical entities were associated with high anti DNA and IgM anti IgG autoantibody titres means reflecting the possible involvement of autoimmunity in the immunopathogenesis of AP. 16-36% of AP cases are expected to have an autoimmune origins.
