Mucosal surfaces play crucial role in immune defenses against human infection diseases. Such mucosal defenses are in a way or other related to systemic defenses mechanisms. A review of ten years works 1999-2009 is being presented. Mucosal infections induces, mucosal and systemic immune response. The systemic response mostly higher than mucosal . The patient herd immunity induces low, moderate and high immune patients, showing normal distribution curves.
