Immunological study of CA-15.3 and CEA tumor markers among post-operative breast cancer patients

الملخص

Breast cancer is a malignant tumor that starts from cells . of the breast. A malignant tumor is a group of cancer cells that may grow into (invade) surrounding tissues or spread (metastasize) to distant areas of the body. The burden of breast cancer is increasing in both developed and developing countries, and in many regions of the world, it is the most frequently occurring malignant disease in women; comprising 18% of all female cancers, and worldwide, breast cancer is the fifth most common cause of cancer mortality. This case-control study was arranged to investigate the possible role of selected genetic and immunological parameters in a random samples of patients with breast cancer in the Al-
Diwanyia province. Five ml blood samples obtained from fifty females with breast cancer in post-operative stage attending the outpatient department of psychiatry in Al-Diwaniyia teaching hospital have been recruited in the study and compared to 50 health control females without any cancer types, ages of patients and control were ranged between 18-80 years. 6ml blood samples were assessed for serum measurement CA-15.3 and CEA tumor markers by using Fully-auto chemiluminescence immunoassay – CMIA. In the association between breast cancer and selected immunological markers our results showed a significant association between serum concentration of tumor markers (CA-15.3 and CEA) and breast cancer disease (p<0.05) in comparison with control group. The mean serum CA-15.3 and CEA were significantly higher in patients as compared to both control groups P value <0.0001. The statistical results show no significant association between CA 15-3 and CEA in patients group (p= 0.185) , but moderate positive correlations is appeared (r = 0.2432). In the other hand the association between patients age and selected immunological markers study in our study (CA-15.3 and CEA) and the results showed to the serum concentrations of CA-15.3 and CEA not effected strongly by Age (r= 0.20 and r= 0.114 respectively ).