Study of Trailer Growth in Candida albicans Associated with Azoles –Drug Resistance
DOI:
https://doi.org/10.28922/qmj.2019.15.2.25-35الكلمات المفتاحية:
Candida albicans، Trailer growth، Azole antifungals، Drug resistanceالملخص
Background:Candida albicans is considered as one of the normal flora that habitat human body and has a virulence capability to cause an opportunistic mycoses,especially in immune-compromised individuals.
Objective:To evaluate the emergence of resistance to azole antifungals in C.albicans associated with trailing growth phenomena.
Methods: Different isolates of C.albicans were identified and tested against azole agents using disk diffusion and microdilution methods to test the antifungals susceptibility profile and determine the resistant isolates depending on the presence of trailer growth phenomena in media after 24-72 hours of incubation .
Results:The antifungals susceptibility profile showed the emergence of trailing growth in C.albicans grown in Sabouraud dextrose agar after 24-48 hours of incubation when tested with azole agents(flucocanozole and ketoconazole) and most of the sensitive and intermediate isolates revealed a trailing growth phenomena.
Conclusion:The present study proved the capability ofC.albicans to resist the azole antifungals even the sensitive isolates when tested toward antifungal drugs .
