The The Prevalence of Endothelial Nitric Oxide Gene Polymorphisms in Iraqi Patients with Essential Hypertension

الملخص

Background: Due to the polygenic character of hypertension, it is particularly challenging to identify the single nucleotide polymorphisms most likely to be linked with essential hypertension and also the connections between certain genes and treatment responses in various ethnic groups. One of important genes is eNOS gene which encode eNOS enzyme that mediate NO production.  Our study involve rs1799983 (G894T) and rs2070744 (T-786C) of eNOS gene. The objective of this observational cross-sectional descriptive study is to examine frequencies of allele of eNOS3 genes. Methods: ninety hypertensive patients were recruited by specialist cardiologist and conducted at AL-Diwaniyah teaching hospital and department of pharmacology and therapeutics, college of medicine, University of Al-Qadisiyah, Iraq. DNA samples were genotyped by PCR-tetra-arm method. Results: Regarding rs1799983 the most frequent allele was G (73%) and the most frequent genotype was GG (55%), while rs2070744 the most frequent allele was T (66%) and the patients had higher frequency of TT + TC genotypes 43%, 47% respectively. Conclusion:  This study concluded the most common allele for rs1799983 was G allele (73%). Regarding rs2070744 the most frequent allele was T (66%).