Angiotensinogen Gene Polymorphism in Iraqi Patient with Essential Hypertension

الملخص

Different genetic and environmental variables contribute to the complicated condition known as essential hypertension. The renin-angiotensin system (RAS) is thought to play a role in controlling blood pressure. In the renin-angiotensin-aldosterone system (RAAS), the AGT is a protein that binds to renin to create angiotensin I, the prohormone of angiotensin II. It is angiotensin II (Ang II)'s precursor, angiotensinogen (AGT), that is responsible for its biological effects. The research took place between July 2022 and July 2023 at the Al-Diwaniyah teaching hospital and the Department of Pharmacology and Therapeutics in the College of Medicine at the University of Al-Qadisiyah in Iraq. Participants ranged in age from 20 to 70, with all having been diagnosed with essential hypertension. There were 90 total. The angiotensinogen gene (AGT) was first implicated as a susceptibility factor in essential hypertension in observational cross-sectional descriptive single-center research. Several AGT variants were recently discovered and investigated in single-center, cross-sectional observational studies. Angiotensinogen gene polymorphism in Iraqi patients with essential hypertension is the focus of this investigation.