A An association between IL-10 (rs1800896) gene polymorphism, and Open angle glaucoma disease susceptibility in Iraqi patients

Primary open angle glaucoma

الملخص

Background_ primary open-angle glaucoma (POAG) is a chronic optic neuropathy that progresses slowly and is characterized by distinctive patterns of optic nerve damage and loss of visual field.  it is  most common type, a complex and multifaceted disease whose pathogenesis is impacted by both environmental and genetic factors.

Objective-The current study's goal is to determine the relationship between IL10 gene polymorphism, and open angle glaucoma disease susceptibility along with their proposed role in disease pathogenesis.

Methods-- Two groups were the subjects of a case-control research:  first group included 40 patients who had previously been diagnosed with glaucoma, all cases that were observed in the General Hospital / Diwaniyah / Eye Department and AL Hayat Hospital. From October 2023 to November 2023 under the supervision of an ophthalmologist, and information was collected about each case. From the patient, in addition to the tests that were performed in the center’s departments, such as: (eye pressure, age, diabetic, smoking and family history of glaucoma). The second group included 40 healthy volunteers (with no family history of glaucoma).

Results- The current investigation found that, when comparing the patient group to the control group, the mean serum IL-10 level was considerably lower., 4.64 ±3.43 versus 6.37 ±2.31, respectively (p = 0.010) Additionally, the current investigation found differences in IL10 genotypes between the patient and control groups. Patients had a considerably higher frequency of the genotype GG (42.5 % versus 5%, respectively) than the control group (p < 0.001). It is therefore a risk factor with a 14.04 odds ratio. Among patients, Comparing the genotype GA to the control group, it was significantly less common (50.0 % versus 87.5%, respectively; p < 0.001). It has an odds ratio of 0.14, making it a protective factor. The frequency of genotype AA in both groups was 7.5% versus 7.5%, respectively, with no discernible difference (p = 1.000).

Conclusion-

 This study clearly showed that the IL10 ( rs1800896) polymorphism are significantly associated with the susceptibility to primary open angle glaucoma in Iraqi patients.