Background: Melasma is an acquired hyper pigmentation disorder recognized by blotchy, light-to-dark brown color macules distributed symmetrically in the sun-exposed parts in the body especially the face due to multiple causing factors including hormonal imbalance.
Aim of study: To detect the pravelance of thyroid disorderes in iraqi patients with melasma and its effect on cardiovascular variables, and to detect the relationship between autoimmune thyroid disorders with melasma.
Materials and methods :The design of the study is a case control study which included 122 subjects (82 melasma patients and 40 control group) where eighty two consenting patients (8 male and 74 female) clinically diagnosed to have melasma and aged 15-45 years (32.05±8.51 years) were included in the study, and fourty healthy volunteer of controls group are included in the study aged 15-45 years (31.6±8.35 years). The males and females were classified into three age groups for each one, fifteen years interval was considered to be suitable for classifying subjects. Patients were investigated for levels of (T3,T4,TSH,TgAb,and TPO).
Results: Melasma were more common in females than males . Also thyroid autoimmunity were more common in females than males. There was no significant difference in (heart rate, blood pressure, mean blood pressure, pulse pressure, and double product) between patients of melasma and control groups. The melasma group value of TSH is significantly higher than that of control group and also the melasma group value of both TgAb, and TPO are significantly higher than that of control group .While no significant difference in T3 and T4.
Conclusion: There were considerable association between melasma and autoimmune thyroid disorders, mostly in females.
