Effect of gentamicin on the histology of renal tubules in different doses, Experimental study

Abstract

The present study showed that the gentamicin cause a mild effect to the proximal convoluted tubules at dose of 5 mg/kg for 14 days represented by loss of brush border. Vacuoles of various sizes appeared with flattening and dilatation of the tubules, condensation of nuclear chromatin was observed, with partial detachment of the cells from the basement membrane. In comparison the more clear effect of gentamicin appears at 10 mg/kg dose that included loss of apical surface and detachment of cells from the basement membrane, with nearly complete loss of brush border and increase in number & size of the cytoplasmic vacuoles. Many nuclei with condensed chromatin and nuclear fragmented cells (apoptosis) were located in tubular lumen. The study concluded that gentamicin has adverse effect on the kidney and renal tubules histology especially in the high dose administration, comparison with low dose that reveal to mild damage.