Studying Profile Of HLA-DQB1 In Patients With Alopecia Areata In Basrah Province

Abstract

A total of 100 individuals were included in this study, 50 patients with alopecia areata and 50 healthy controls. There was no significant difference between alopecia areata patients and controls according to gender and age groups. No significant difference between alopecia areata patients and controls according to age groups. HLA-DQB1 alleles were studied in those patients and compared with HLA-DQB1 in healthy controls. A significant decreased frequency of HLA-DQB1*020101 and HLA-DQB1*030201 alleles in patients with alopecia areata comparing with healthy controls (P < 0.05, OR= 0.76, 95% CI= 0.65-0.89) and (P < 0.05, OR= 0.72, 95% CI= 0.61-0.86) respectively. HLA-DQB1*030101, HLA-DQB1*060101 and HLA-DQB1*060201 showed significant increased frequencies in alopecia areata patients comparing with healthy controls, (< 0.05, OR= 0.24, 95% CI= 0.06-1.10), (P < 0.05, OR= 1.23, 95% CI= 0.97-1.56) and (P < 0.05, OR= 1.46, 95% CI= 1.05-2.02) respectively. There was no significant difference in HLA-DQB1 alleles in patients with family history of alopecia areata and patients without family history of alopecia areata. Patients with alopecia areata showed increased homozygousity in HLA-DQB1 when compared with controls (P <0.005, OR= 0.05, 95% CI= 0.01-0.23). Combination of HLA-DQA1*0103 – HLA-DQB1*0301 showed higher frequency in comparison with other HLA-DQA1-HLA-DQB1 alleles combinations