Evaluation of serum levels Interferon gamma , Interleukin 10 and the ratio between them in patients with vitiligo
Association of Interferon gamma : Interleukin 10 cytokine ratio in vitiligo patients
DOI:
https://doi.org/10.28922/qmj.v20i1.943Keywords:
Vitiligo, Interleukin 10, Interferon gamma, RatioAbstract
Abstract
Background and Objective : In the process of depigmenting vitiligo, cytokines, which control immune response and inflammation, are essential. In this investigation, serum levels of interferon gamma (IFN-?) and interleukin 10 (IL-10) and their the ratio were compared in healthy people and those with vitiligo in Iraqi.
Materials and method : In order to conduct the study, samples from 60 patients were collected, while samples from 60 healthy participants (the control group) were pooled and measured using sandwich ELISA. Data on the patient's gender, family history, disease state, stress exposure, and males smoking habits are collected as part of the study.
Results : When compared to controls, vitiligo patients had higher amounts of IFN- ???? while lower levels of interleukin 10. IFN-? to IL-10 ratio varied substantially among patients as well as controls. Concerning physical the differences, disease stability, and male smokers, there have been substantial distinctions between both IFN- ???? concentrations and the IFN-? to IL-10 ratio. IFN -???? : IL -10 ratio was substantially correlated having a history of vitiligo in their family, but, not at each molecule's level.
Conclusion : It could be concluded that patients with vitiligo have an elevated IFN- ???? serum level. The levels of serum IL-10 was lower than in patients with vitiligo in comparison with healthy control. A possible solution of potential immunologic indicators for vitiligo is the ratio of serum levels of IFN-? to IL-10.
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