Neonatal septicemia in AL_Najaf AL_Ashref governerate : bacteriological profile and antimicrobial sensitivity

Abstract

Neonatal septicemia still one of the most important causes of neonatal sepsis and death. Knowledge of bacteriological profile and antibacterial sensitivity pattern in our locality play an important role in selection of antibacterial drug that will be very effective against causative pathogens.This study conducted in AL- NAJAF AL- ASHREF Governorate during period extended between Nov.2007 to Feb.-2008, about 57 clinically suspected cases of neonatal septicemia was enrolled, to study bacteriological profile and antibiotic sensitivity pattern. Results showed that 33 cases (58 %) gave positive blood culture results and there was no growth in 24 cases (42 %), from the positive cases there was 20 males and 13 females.On the other hand, Klebsiella sp. represented 42.4% of all isolates and Escherichia coli were 27.2 %, while the rest (30.29 %) was represented by Staphylococcus aureus. Sensitivity pattern showed that S.aureus was sensitive to Norfloxacin (100 %), Vancomycin (85.7 %), Netilmicin (66.6 %), Teicoplanin (66.6 %) and Azithromycin (42.8 %). While Klebsiella sp. was sensitive to Amikacin (100 %), Norfloxacin (100 %), Nalidixic acid (100 %), Doxycycline (50 %), Cephalexin (0 %) and Gentamycin (0 %).While E.coli was sensitive (100 %) to Norfloxacin, (100 %) for Amikacin, (100 %) for Tobramycin, (50%) to cefotaxime and (50 %) for Nalidixic acid. These results will help the physician in our locality to select most sensitive drug by the bacteria for optimum successful treatment to overcome morbidity and mortality in neonate.