Oxidant/Antioxidant Status, C-reactive Protein and Serum Leptin in Patients with Pulmonary Tuberculosis: Effect of Vitamin E Supplemention

الملخص

Objectives: To evaluate the effects of pulmonary Tuberculosis (TB) on markers of oxidative stress (malondialdehyde "MDA" and total antioxidant status "TAS"), high sensitivity C-reactive protein (hs-CRP) and serum leptin and to compare the effects of standard intensive 2 months anti-TB therapy with the standard intensive anti-TB therapy plus vitamin E supplementation on the parameters. Methods: Two group of patients with active pulmonary TB from the Advisory Clinic for Chest and Respiratory Diseases in Mosul City were included in this study.Group one consistent of 38 patients and group two consistent of 28 patients, with forty healthy age and sex matched subjects as controls. Assessment of concentrations of MDA, TAS, hs- CRP and leptin were done for both patients and controls. After two months with either the traditional intensive therapy (isoniazid "INH" 75 mg, rifampicin 150mg, pyrazinamide 400mg and ethambutol 275mg ) 4 tablets as a single dose in the morning with vitamin B6 10mg daily or , the intensive traditional therapy plus vitamin E 400 IU/day as a supplementation therapy, the same parameters were reassessed for the patients. Body mass index(BMI) were calculated by using special equation.
Results: After 2 months of either the traditional therapy or the traditional therapy plus vitamin E ,there was a significant reduction in
MDA and hs-CRP with significant increase in TAS ,leptin serum levels and BMI in patients with pulmonary TB in comparison to pre-therapy stage and the percentage of variation shifted towards the beneficial effect of vitamin E add- on therapy group.
Conclusion: Active pulmonary TB associated with oxidative stress and an increase in the levels of hs-CRP and both traditional therapy or the traditional therapy plus vitamin E resulted in a significant improvement in oxidative stress and cause suppression of inflammatory responses with the beneficial effects shifted towards the add-on of vitamin E as a supplementation therapy.