The Effect of Inhalation Treatment on Oxidative Stress in Asthmatic Patients

Abstract

The present study was conducted to verify the oxidative stress status in asthma patients . To achieve this aim, ninty asthmatic patients, and thirty healthy subjects (control group) were subjected to the study the sample were obatained from Babylon Asthma and Allergy Center in Hilla City .. showed The results of this study in asthmatic patients (men and menopause women ) with steroid inhalation treatment group when compared with control group showed a significant increase of Malondialdehyde (MDA) ,amd a significant decrease of super oxidase dismutase (SOD) and creatine kinase(CK) levels (P < 0.05 ) , wherease there was non significant increase in glutathione-S-transferase (GST), levels( P < 0.05) . The results of this study for asthmatic patients (men and menopause women ) with steroid inhalation treatment group when compared with asthmatic patients without treatment indicated a significant increasing levels of super oxidase dismutase (SOD) (SOD) , glutathione-S-transferase (GST) of men (P < 0.05) , whereas there was a non significant increase in levels of creatine kinase(CK), glutathione-S-transferase (GST) of menopause women(P<0.05) but there was significant decrease in malondialdehyde (MDA) levels. In asthmatic patients (men and menopause women ) without treatment group when compared with those of control group estimated significant decrease of super oxidase dismutase (SOD) (SOD) and creatine kinase(CK) level ( P < 0.05) , wherease there was a non significant increase in GST but there was a significant increase in malondialdehyde (MDA) levels ,( P < 0.05) . The correlation analysis indicated a non significant negative correlation in period of treatment with superoxide dismutase (SOD) and creatine kinase(CK) , as well as a non significant positive correlation for glutathione-S-transferase (GST) and malondialdehyde (MDA) .